Anatabine reduces Cox-2 and iNOS mRNA expression in brain of Tg PS1/APPswe mice.

The histogram represents quantitative results from RT-qPCR analysis calculated using the Delta-Delta Ct Method. The means ± SEM Cox-2 and iNOS mRNA levels are expressed as relative fold change compared to control (wild-type placebo). ANOVA shows a significant main effect of the treatments on Cox-2 and iNOS transcription (P<0.001). Post-hoc analyses reveal a significant difference in Cox-2 and iNOS mRNA levels between Tg PS1/APPswe placebo and anatabine treated mice 10 mg/Kg/Day (P<0.02 for iNOS) and 20 mg/Kg/Day (P<0.001 for iNOS and P<0.001 for COX-2).