Anatabine improves social interaction and social memory in Tg PS1/APPswe mice.

A) The histogram represents the mean time spent ± SEM by Tg PS1/APPswe and their control wild-type littermates mouse receiving regular drinking water in the chamber containing the Stranger1 and the empty cage for the social interaction phase of 3-chamber test. B) The histogram represents the time spent ± SEM by Tg PS1/APPswe receiving regular drinking water or anatabine at a dosage of 10 and 20 mg/Kg/Day in the chamber containing the Stranger 1 and the empty cage for the social interaction phase of 3-chamber test. Tg PS1/APPswe mice receiving regular drinking water spent the same amount of time in the chamber containing the stranger 1 and the empty cage (P>0.05). Tg PS1/APPswe mice receiving anatabine at a dosage of 20mg/Kg/Day spent significantly more time exploring the chamber containing the Stranger1 than the chamber containing the empty cage (P<0.04). C) The histogram represents the time spent ± SEM by Tg PS1/APPswe and their control wild-type littermate mouse in the chamber containing the Stranger1 and the Stranger 2 for the social memory phase of 3-chamber test. D) The histogram represents the time spent ± SEM by Tg PS1/APPswe receiving regular drinking water or anatabine at a dosage of 10 and 20 mg/Kg/Day in the chamber containing the Stranger 1 and in the chamber containing the Stranger 2. Tg PS1/APPswe mice receiving regular drinking water showed no preference for social novelty, as they spent an equal amount of time in the chamber containing the Stranger 1 and in the chamber containing the Stranger 2 (P>0.05). Tg PS1/APPswe mice receiving anatabine at a dosage of 10 and 20 mg/Kg/Day spent significantly more time exploring the chamber containing the unfamiliar Stranger 2 than the chamber containing the previously encountered mouse (Stranger 1) (P<0.015 and P<0.003 respectively).