TY - DATA T1 - Anatabine reduces Cox-2 and iNOS mRNA expression in brain of Tg PS1/APPswe mice. PY - 2015/05/26 AU - Megha Verma AU - David Beaulieu-Abdelahad AU - Ghania Ait-Ghezala AU - Rena Li AU - Fiona Crawford AU - Michael Mullan AU - Daniel Paris UR - https://plos.figshare.com/articles/figure/_Anatabine_reduces_Cox_2_and_iNOS_mRNA_expression_in_brain_of_Tg_PS1_APPswe_mice_/1425757 DO - 10.1371/journal.pone.0128224.g010 L4 - https://ordo.open.ac.uk/ndownloader/files/2081910 KW - anatabine treatment KW - stat KW - ad KW - ps KW - nf KW - Chronic Anatabine Treatment KW - chemical structure similarity KW - Mouse Model KW - β deposits KW - tg KW - Transgenic Mouse Model N2 - The histogram represents quantitative results from RT-qPCR analysis calculated using the Delta-Delta Ct Method. The means ± SEM Cox-2 and iNOS mRNA levels are expressed as relative fold change compared to control (wild-type placebo). ANOVA shows a significant main effect of the treatments on Cox-2 and iNOS transcription (P<0.001). Post-hoc analyses reveal a significant difference in Cox-2 and iNOS mRNA levels between Tg PS1/APPswe placebo and anatabine treated mice 10 mg/Kg/Day (P<0.02 for iNOS) and 20 mg/Kg/Day (P<0.001 for iNOS and P<0.001 for COX-2). ER -