10.1371/journal.pone.0128224.g010
Megha Verma
Megha
Verma
David Beaulieu-Abdelahad
David
Beaulieu-Abdelahad
Ghania Ait-Ghezala
Ghania
Ait-Ghezala
Rena Li
Rena
Li
Fiona Crawford
Fiona
Crawford
Michael Mullan
Michael
Mullan
Daniel Paris
Daniel
Paris
Anatabine reduces <i>Cox-2</i> and <i>iNOS</i> mRNA expression in brain of Tg PS1/APPswe mice.
Public Library of Science
2015
anatabine treatment
stat
ad
ps
nf
Chronic Anatabine Treatment
chemical structure similarity
Mouse Model
β deposits
tg
Transgenic Mouse Model
2015-05-26 15:04:00
Figure
https://plos.figshare.com/articles/figure/_Anatabine_reduces_Cox_2_and_iNOS_mRNA_expression_in_brain_of_Tg_PS1_APPswe_mice_/1425757
<p>The histogram represents quantitative results from RT-qPCR analysis calculated using the Delta-Delta Ct Method. The means ± SEM <i>Cox</i>-2 and <i>iNOS</i> mRNA levels are expressed as relative fold change compared to control (wild-type placebo). ANOVA shows a significant main effect of the treatments on <i>Cox-2</i> and <i>iNOS</i> transcription (P<0.001). Post-hoc analyses reveal a significant difference in <i>Cox</i>-<i>2</i> and <i>iNOS</i> mRNA levels between Tg PS1/APPswe placebo and anatabine treated mice 10 mg/Kg/Day (P<0.02 for <i>iNOS</i>) and 20 mg/Kg/Day (P<0.001 for <i>iNOS</i> and P<0.001 for <i>COX-2</i>).</p>