Verma, Megha Beaulieu-Abdelahad, David Ait-Ghezala, Ghania Li, Rena Crawford, Fiona Mullan, Michael Paris, Daniel Anatabine reduces the amount of phosphorylated p65 NFκB immunopositive cells associated with β-amyloid deposits in the cortex of Tg PS1/APPswe mice. <p>A) Representative 40X microscopic field revealing the presence of phosphorylated p65 NFκB immunopositive cells around Congo red stained β-amyloid deposits in the cortex of Tg PS1/APPswe mice receiving regular drinking water (placebo) or anatabine at a dosage of 10 and 20 mg/Kg/Day in their drinking water. Data is presented as mean±SEM. B) The histogram represents the average amount of phospho p65 NFκB burden (expressed as a percentage of the brain area examined) associated with β-amyloid deposits in the cortex Tg PS1/APPswe receiving regular drinking water (placebo) and the anatabine treatment at a dosage of 10 and 20 mg/Kg/Day. ANOVA shows a statistically significant main effect of the anatabine treatment on phosphorylated p65 NFκB immunoreactive cells associated with Aβ deposits (P<0.001). Post-hoc comparisons reveal statistically significant differences between Tg PS1/APPswe receiving regular drinking water (placebo) and anatabine at a dosage of 10 mg/Kg/Day (P<0.001) and 20 mg/Kg/Day (P<0.001) for the amount of p65 NFκB phosphorylation associated with β-amyloid burden.</p> anatabine treatment;stat;ad;ps;nf;Chronic Anatabine Treatment;chemical structure similarity;Mouse Model;β deposits;tg;Transgenic Mouse Model 2015-05-26
    https://plos.figshare.com/articles/figure/_Anatabine_reduces_the_amount_of_phosphorylated_p65_NF_954_B_immunopositive_cells_associated_with_946_amyloid_deposits_in_the_cortex_of_Tg_PS1_APPswe_mice_/1425753
10.1371/journal.pone.0128224.g007